Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions First author’s surname and short title: Broisat - Imaging Atherosclerosis with Anti-VCAM1 Nanobodies
نویسندگان
چکیده
1 Radiopharmaceutiques Biocliniques, INSERM, 1039, Université de Grenoble, La Tronche, France 2 In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Brussels, Belgium 3 Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium 4 Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium 5 Laboratoire d'Enzymologie Moléculaire CNRS UMR 5075, IBS, Grenoble, France, 6 Central Veterinary Research Laboratory, Dubai, United Arab Emirates 7 Nuclear Medicine Department, UZ Brussel, Brussels, Belgium * Authors contributed equally
منابع مشابه
Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions.
RATIONALE A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies represent potential radiotracers for cardiovascular molecular imaging. Vascular cell adhesion molecule-1 (VCAM1) constitutes a relevant target for molecular imaging of atherosclerotic lesions. OBJECTIVE We aimed to g...
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Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies represent potential radiotracers for cardiovascular molecular imaging. Vascular cell adhesion molecule-1 (VCAM1) constitutes a relevant target for molecular imaging of atherosclerotic lesions. Objective: We aimed to g...
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